Treatment with 0.3% adapalene gel / 2.5% benzoyl peroxide (0.3% A / BPO) was tolerable, safe and improved quality of life (QoL) in ...
Treatment with 0.3% adapalene gel / 2.5% benzoyl peroxide (0.3% A / BPO) was tolerable, safe and improved quality of life (QoL) in a study of colored patients with moderate or severe facial acne. , In addition, the treatment has helped patients achieve a clear / almost unambiguous assessment of the state of the art from researchers worldwide. The results of this study were published in the Journal of Drugs in Dermatology .
The open-label study included persons with Asian (n = 20), Latin American (n = 13) and black / African American (n = 17) ethnic origin who had moderate facial acne (70%). ) or heavy (30%) and mainly Fitzpatrick skins of types IV to VI. Patients had 25 to 100 inflammatory lesions, 30 to 150 non-inflammatory lesions, and 2 or fewer acne nodules.
Participants applied 0.3% A / BPO once daily for a period of 16 weeks, in addition to an oil control foam wash twice daily and oil control once daily with Moisturizer. The moisturizer with sun protection factor was reapplied throughout the day when the Patients were exposed to the sun.
At the beginning of the study, as well as in weeks 12 and 16, the questionnaires on the dermatological quality of life index or on the dermatological quality of life index for children (for children under the age of 16) were filled. The satisfaction questionnaires were filled in both weeks 12 and 16.
Overall, around 88% of all participants stated that they were satisfied or very satisfied with their treatment. Three-quarters (77%) of patients were satisfied or very satisfied with treatment at week 16. Most patients felt unwell or slightly unwell (93%) with the side effects of the treatment. Almost half (49%) did not care about side effects.
In terms of effectiveness of 0.3% A / BPO, more than half (56%) of the participants achieved a total score of 0 or 1, which is clear / almost unique. In addition, the majority of patients (87%) showed a good to excellent improvement in the overall rating of the improvement.
All participants reported an improvement in the quality of life. The number of participants who "had no impact at all" on quality of life from the beginning to the 16th week increased by 16% to 55%. Postinflammatory hyperpigmentation was found to be very mild to moderate (60%) at the beginning of the study, while 75% had no or very mild postinflammatory hyperpigmentation at week 16 (mean decrease of 27%). %). No adverse events related to discontinuation of the study were reported.
Limitations of the study include open design, a low number of patients in the general sample, and the absence of white patients, which may limit the generalization of results.
The researchers concluded that moisturizers and sunscreens in combination with 0.3% A / BPO gel "are essential and, when combined with acne treatment, result in high levels of satisfaction with the subject" improved adhesion and favorable tolerability ".
Disclosure: This clinical trial was supported by Galderma R & D. For a complete list of authors' disclosures, see the original.
Reference:
DuBois J., GCW Ong., Petkar G. et al. Patient reported results in patients with stained skin acne using 0.3% adapalene benzoyl peroxide 2.5%: prospective study in practice. J Dermatol medication . 2019; 18 (6): 514.
